Stimulating Extracellular Vesicles Production from Engineered Tissues by Mechanical Forces

Shaowei Guo Lior Debbi Barak Zohar Roee Samuel Roni S.Arzi Adina I.Fried Tahel Carmon Dudi Shevach Idan Redenski Inbar Schlachet Alejandro Sosnik Shulamit Levenberg

【摘要】：正Background: Extracellular vesicles (EVs) have emerged as a promising strategy to promote tissue regeneration. However, overcoming the low EV production yield remains a big challenge in translating EV-based therapies to the clinical practice. Current EV production relies heavily on 2D cell culture, which is not only less physiologically relevant to cells, but also requires substantial medium and space. Therefore, we aimed to boost EVs secretion by a novel method combining tissue engineering and biomechanics.

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