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Stimulating Extracellular Vesicles Production from Engineered Tissues by Mechanical Forces

Shaowei Guo  Lior Debbi  Barak Zohar  Roee Samuel  Roni S.Arzi  Adina I.Fried  Tahel Carmon  Dudi Shevach  Idan Redenski  Inbar Schlachet  Alejandro Sosnik  Shulamit Levenberg  
【摘要】:正Background: Extracellular vesicles (EVs) have emerged as a promising strategy to promote tissue regeneration. However, overcoming the low EV production yield remains a big challenge in translating EV-based therapies to the clinical practice. Current EV production relies heavily on 2D cell culture, which is not only less physiologically relevant to cells, but also requires substantial medium and space. Therefore, we aimed to boost EVs secretion by a novel method combining tissue engineering and biomechanics.

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